AID Elispot Reader

研究主題

TB Diagnostics
HIV Infection
Epstein Barr virus
HCV
Diabetes Mellitus
Allergy
Allograft

TB Diagnostics

Incidence of Tuberculosis and the Predictive Value of ELISPOT and Mantoux Tests in Gambian Case Contacts.

Hill PC, Jackson-Sillah DJ, Fox A, Brookes RH, de Jong BC, Lugos MD, Adetifa IM, Donkor SA, Aiken AM, Howie SR, Corrah T, McAdam KP, Adegbola RA.

PLoS ONE, January 2, 2008 , 3(1): e1379.

Screening of Highly Expressed Mycobacterial Genes Identifies Rv3615c as a Useful Differential Diagnostic Antigen for the Mycobacterium tuberculosis Complex.

Sidders B, Pirson C, Hogarth PJ, Hewinson RG, Stoker NG, Vordermeier HM, Ewer K.

Infection and Immunity, September 2008, p. 3932-3939, Vol. 76, No. 9

Longitudinal assessment of an ELISPOT test for Mycobacterium tuberculosis infection.

Philip C. Hill, Roger H. Brookes, Annette Fox, Dolly Jackson-Sillah, David J. Jeffries, Moses D. Lugos, Simon A. Donkor, Ifedayo M. Adetifa, Bouke C. de Jong, Alex M. Aiken, Richard A. Adegbola, Keith P. McAdam

PLoS Medicine, June 2007 ;4(6):e192

Using ELISPOT to Expose False Positive Skin Test Conversion in Tuberculosis Contacts.

Hill PC, Jeffries DJ, Brookes RH, Fox A, Jackson-Sillah D, Lugos MD, Donkor SA, de Jong BC, Corrah T, Adegbola RA, McAdam KP.

PLoS ONE, January 31, 2007, 2(1): e183.

Reversion of the ELISPOT test after treatment in Gambian tuberculosis cases.

Alexander M Aiken, Philip C Hill, Annette Fox, Keith PWJ McAdam, Dolly Jackson-Sillah, Moses D Lugos, Simon A Donkor, Richard A Adegbola and Roger H Brookes.

BMC Infectious Diseases 2006, 30 March 2006 6:66

Phase I therapeutic trial of the HIV-1 Tat protein and long term follow-up.

Longo O, Tripiciano A, Fiorelli V, Bellino S, Scoglio A, Collacchi B, Alvarez MJ, Francavilla V, Arancio A, Paniccia G, Lazzarin A, Tambussi G, Din CT, Visintini R, Narciso P, Antinori A, D’Offizi G, Giulianelli M, Carta M, Di Carlo A, Palamara G, Giuliani M, Laguardia ME, Monini P, Magnani M, Ensoli F, Ensoli B.

Vaccine Volume27, Issues 25-26, 26 May 2009, Pages 3306-3312

A Phase 1 Study to Evaluate the Safety and Immunogenicity of a Recombinant HIV Type 1 Subtype C-Modified Vaccinia Ankara Virus Vaccine Candidate in Indian Volunteers.

Ramanathan VD, Kumar M, Mahalingam J, Sathyamoorthy P, Narayanan PR, Solomon S, Panicali D, Chakrabarty S, Cox J, Sayeed E, Ackland J, Verlinde C, Vooijs D, Loughran K, Barin B, Lombardo A, Gilmour J, Stevens G, Smith MS, Tarragona-Fiol T, Hayes P, Kochhar S, Excler JL, Fast P.

AIDS Research and Human Retroviruses. November 2009, 25(11): 1107-1116.

Targeting of a CD8 T Cell Env Epitope Presented by HLA-B*5802 Is Associated with Markers of HIV Disease Progression and Lack of Selection Pressure.

Ngumbela KC, Day CL, Mncube Z, Nair K, Ramduth D, Thobakgale C, Moodley E, Reddy S, de Pierres C, Mkhwanazi N, Bishop K, van der Stok M, Ismail N, Honeyborne I, Crawford H, Kavanagh DG, Rousseau C, Nickle D, Mullins J, Heckerman D, Korber B, Coovadia H, Kiepiela P, Goulder PJ, Walker BD.

AIDS Research and Human Retroviruses, January 15, 2008, Volume: 24 Issue 1

Early therapy in HIV-1-infected children: effect on HIV-1 dynamics and HIV-1-specific immune response.

Zanchetta M, Anselmi A, Vendrame D, Rampon O, Giaquinto C, Mazza A, Accapezzato D, Barnaba V, De Rossi A.

Antiviral Therapy. 2008;13(1):47-55.

Studies of a prophylactic HIV-1 vaccine candidate based on modified vaccinia virus Ankara (MVA) with and without DNA priming: Effects of dosage and route on safety and immunogenicity.

Barry S. Peters, Walter Jaoko, Eftyhia Vardas, George Panayotakopoulos, Patricia Fast, Claudia Schmidt, Jill Gilmour, Mampedi Bogoshi, Gloria Omosa-Manyonyi, Len Dally, Linda Klavinskis, Bashir Farah, Tony Tarragona, Pierre-Alexandre Bart, Andrew Robinson, Colleen Pieterse, Wendy Stevens, Richard Thomas, Burc Barin, Andrew J. McMichael, James A. McIntyre, Giuseppe Pantaleo, Tomas Hanke and Job Bwayo

Vaccine Volume 25, Issue 11, 1 March 2007, Pages 2120-2127

Distinct memory CD4+ T-cell subsets mediate immune recognition of Epstein Barr virus nuclear antigen 1 in healthy virus carriers.

Heller KN, Upshaw J, Seyoum B, Zebroski H, Münz C.

Blood, 1 February 2007, Vol. 109, No. 3, pp. 1138-1146.

Spontaneous Recovery in Acute Human Hepatitis C Virus Infection: Functional T-Cell Thresholds and Relative Importance of CD4 Help.

Susan Smyk-Pearson, Ian A. Tester, Jared Klarquist, Brent E. Palmer, Jean-Michel Pawlotsky, Lucy Golden-Mason, and Hugo R. Rosen

Journal of Virology, February 2008, p. 1827-1837, Vol. 82, No. 4

Outcome of acute hepatitis C is related to virus-specific CD4 function and maturation of antiviral memory CD8 responses.

Simona Urbani, Barbara Amadei, Paola Fisicaro, Daniela Tola, Alessandra Orlandini, Luca Sacchelli, Cristina Mori, Gabriele Missale, Carlo Ferrari

Hepatology, July 2006, Volume 44, Issue 1, pages 126–139

Early impairment of hepatitis C virus specific T cell proliferation during acute infection leads to failure of viral clearance.

Folgori A, Spada E, Pezzanera M, Ruggeri L, Mele A, Garbuglia AR, Perrone MP, Del Porto P, Piccolella E, Cortese R, Nicosia A, Vitelli A; Acute Hepatitis C Italian Study Group.

Gut. 2006 Jul;55(7):1012-9. Epub 2006 Feb 16.

Hepatitis C virus carriers with persistently normal ALT levels: biological peculiarities and update of the natural history of liver disease at 10 years.

Persico M, Perrotta S, Persico E, Terracciano L, Folgori A, Ruggeri L, Nicosia A, Vecchione R, Mura VL, Masarone M, Torella R.

Journal of Viral Hepatitis, Volume 13, Issue 5, pages 290–296, May 2006

Efficient immunization of rhesus macaques with an HCV candidate vaccine by heterologous priming–boosting with novel adenoviral vectors based on different serotypes.

E Fattori, I Zampaglione, M Arcuri, A Meola, B B Ercole, A Cirillo, A Folgori, A Bett, M Cappelletti, E Sporeno, R Cortese, A Nicosia and S Colloca

Gene Therapy (2006) 13, 1088–1096

Diminished Th1-Like Response to Autoantigens in Children with a High Risk of Developing Type 1 Diabetes.

Karlsson Faresjö MG, Ludvigsson J.

Scandinavian Journal of Immunology, Volume 61, Issue 2, pages 173–179, February 2005

Comparison of cytokine ELISpot assay formats for the detection of islet antigen autoreactive T cells: Report of the third immunology of diabetes society T-cell workshop.

Nanette C. Schloot, Guido Meierhoff, Maria Karlsson Faresjö, Patrick Ott, Amy Putnam, Paul Lehmann, Peter Gottlieb, Bart O. Roep, Mark Peakman and Timothy Tree

Journal of Autoimmunity Volume 21, Issue 4, December 2003, Pages 365-376

研究主題

TB Diagnostics

Incidence of Tuberculosis and the Predictive Value of ELISPOT and Mantoux Tests in Gambian Case Contacts.

Screening of Highly Expressed Mycobacterial Genes Identifies Rv3615c as a Useful Differential Diagnostic Antigen for the Mycobacterium tuberculosis Complex.

Longitudinal assessment of an ELISPOT test for Mycobacterium tuberculosis infection.

Using ELISPOT to Expose False Positive Skin Test Conversion in Tuberculosis Contacts.

Reversion of the ELISPOT test after treatment in Gambian tuberculosis cases.

HIV Infection

Phase I therapeutic trial of the HIV-1 Tat protein and long term follow-up.

A Phase 1 Study to Evaluate the Safety and Immunogenicity of a Recombinant HIV Type 1 Subtype C-Modified Vaccinia Ankara Virus Vaccine Candidate in Indian Volunteers.

Targeting of a CD8 T Cell Env Epitope Presented by HLA-B*5802 Is Associated with Markers of HIV Disease Progression and Lack of Selection Pressure.

Early therapy in HIV-1-infected children: effect on HIV-1 dynamics and HIV-1-specific immune response.

Studies of a prophylactic HIV-1 vaccine candidate based on modified vaccinia virus Ankara (MVA) with and without DNA priming: Effects of dosage and route on safety and immunogenicity.

Epstein Barr viru

Distinct memory CD4+ T-cell subsets mediate immune recognition of Epstein Barr virus nuclear antigen 1 in healthy virus carriers.

HCV

Spontaneous Recovery in Acute Human Hepatitis C Virus Infection: Functional T-Cell Thresholds and Relative Importance of CD4 Help.

Outcome of acute hepatitis C is related to virus-specific CD4 function and maturation of antiviral memory CD8 responses.

Early impairment of hepatitis C virus specific T cell proliferation during acute infection leads to failure of viral clearance.

Hepatitis C virus carriers with persistently normal ALT levels: biological peculiarities and update of the natural history of liver disease at 10 years.

Efficient immunization of rhesus macaques with an HCV candidate vaccine by heterologous priming–boosting with novel adenoviral vectors based on different serotypes.

Diabetes Mellitus

Diminished Th1-Like Response to Autoantigens in Children with a High Risk of Developing Type 1 Diabetes.

Comparison of cytokine ELISpot assay formats for the detection of islet antigen autoreactive T cells: Report of the third immunology of diabetes society T-cell workshop.

Allergy

Early-life viral infection and allergen exposure interact to induce an asthmatic phenotype in mice.

Elevated Peripheral Allergen-Specific T Cell Response Is Crucial for a Positive Atopy Patch Test Reaction.

HMGB1-secreting capacity of multiple cell lineages revealed by a novel HMGB1 ELISPOT assay

Allograft

Autoantibodies to Vimentin Cause Accelerated Rejection of Cardiac Allografts.

Humoral and Cellular Responses to Influenza Vaccination in Human Recipients Naturally Tolerant to a Kidney Allograft.

AID Elispot Reader

研究主題

TB Diagnostics

Incidence of Tuberculosis and the Predictive Value of ELISPOT and Mantoux Tests in Gambian Case Contacts.

Screening of Highly Expressed Mycobacterial Genes Identifies Rv3615c as a Useful Differential Diagnostic Antigen for the Mycobacterium tuberculosis Complex.

Longitudinal assessment of an ELISPOT test for Mycobacterium tuberculosis infection.

Using ELISPOT to Expose False Positive Skin Test Conversion in Tuberculosis Contacts.

Reversion of the ELISPOT test after treatment in Gambian tuberculosis cases.

HIV Infection

Phase I therapeutic trial of the HIV-1 Tat protein and long term follow-up.

A Phase 1 Study to Evaluate the Safety and Immunogenicity of a Recombinant HIV Type 1 Subtype C-Modified Vaccinia Ankara Virus Vaccine Candidate in Indian Volunteers.

Targeting of a CD8 T Cell Env Epitope Presented by HLA-B*5802 Is Associated with Markers of HIV Disease Progression and Lack of Selection Pressure.

Early therapy in HIV-1-infected children: effect on HIV-1 dynamics and HIV-1-specific immune response.

Studies of a prophylactic HIV-1 vaccine candidate based on modified vaccinia virus Ankara (MVA) with and without DNA priming: Effects of dosage and route on safety and immunogenicity.

Epstein Barr viru

Distinct memory CD4+ T-cell subsets mediate immune recognition of Epstein Barr virus nuclear antigen 1 in healthy virus carriers.

HCV

Spontaneous Recovery in Acute Human Hepatitis C Virus Infection: Functional T-Cell Thresholds and Relative Importance of CD4 Help.

Outcome of acute hepatitis C is related to virus-specific CD4 function and maturation of antiviral memory CD8 responses.

Early impairment of hepatitis C virus specific T cell proliferation during acute infection leads to failure of viral clearance.

Hepatitis C virus carriers with persistently normal ALT levels: biological peculiarities and update of the natural history of liver disease at 10 years.

Efficient immunization of rhesus macaques with an HCV candidate vaccine by heterologous priming–boosting with novel adenoviral vectors based on different serotypes.

Diabetes Mellitus

Diminished Th1-Like Response to Autoantigens in Children with a High Risk of Developing Type 1 Diabetes.

Comparison of cytokine ELISpot assay formats for the detection of islet antigen autoreactive T cells: Report of the third immunology of diabetes society T-cell workshop.

Allergy

Early-life viral infection and allergen exposure interact to induce an asthmatic phenotype in mice.

Elevated Peripheral Allergen-Specific T Cell Response Is Crucial for a Positive Atopy Patch Test Reaction.

HMGB1-secreting capacity of multiple cell lineages revealed by a novel HMGB1 ELISPOT assay

Allograft

Autoantibodies to Vimentin Cause Accelerated Rejection of Cardiac Allografts.

Humoral and Cellular Responses to Influenza Vaccination in Human Recipients Naturally Tolerant to a Kidney Allograft.

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