結腸炎研究的黃金標準。炎症性腸病是一種病因不明的多因素疾病,由兩種主要亞型組成,即潰瘍性結腸炎 (ulcerative colitis) 和克羅恩病 (Crohn’s disease)。硫酸葡聚醣 (Dextran sulfate sodium, DSS) 用於誘導動物的結腸炎的實驗。改變硫酸葡聚醣 (Dextran sulfate sodium, DSS) 的濃度或劑量的周期可以容易地誘發急性,慢性或複發性結腸炎。
什麼是硫酸葡聚醣 (Dextran sulfate sodium, DSS)?
硫酸葡聚醣 (Dextran sulfate sodium, DSS) 是帶負電荷的硫酸化葡聚醣,分子量為 40000Da。硫酸葡聚醣 (Dextran sulfate sodium, DSS) 廣泛用於在小鼠模型中誘導結腸炎。當硫酸葡聚醣 (Dextran sulfate sodium, DSS) 在飲用水中口服給藥時,誘發腸道炎症 (induce colitis)。使用 2%至 5%的濃度,在一周內出現症狀。
正常的老鼠腸組織
使用 DSS 誘導的腸組織使用 3% DSS 於飲用水中,作用 7 天。
如果您需要更大量的硫酸葡聚醣 (Dextran sulfate sodium, DSS),請立即聯絡我們取得報價。
參考文獻
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2011-2000
- Villegas, I., Sánchez‐Fidalgo, S. & Lastra, C. A. de la. Chemopreventive effect of dietary curcumin on inflammation-induced colorectal carcinogenesis in mice. Molecular Nutrition & Food Research 55, 259–267 (2011).
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- Queiroz, K. C. S. et al. Tissue Factor-Dependent Chemokine Production Aggravates Experimental Colitis. Mol Med 17, 1119–1126 (2011).
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- Lenoir, L. et al. Lemon Verbena Infusion Consumption Attenuates Oxidative Stress in Dextran Sulfate Sodium-Induced Colitis in the Rat. Dig Dis Sci 56, 3534–3545 (2011).
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- Deboer, M. D. & Li, Y. Puberty Is Delayed in Male Mice With Dextran Sodium Sulfate Colitis Out of Proportion to Changes in Food Intake, Body Weight, and Serum Levels of Leptin. Pediatric Research 69, 34–39 (2011).
- Cançado, G. G. L. et al. Hookworm products ameliorate dextran sodium sulfate-induced colitis in BALB/c mice. Inflamm Bowel Dis 17, 2275–2286 (2011).
- Banerjee, S. et al. Balance of meprin A and B in mice affects the progression of experimental inflammatory bowel disease. American Journal of Physiology-Gastrointestinal and Liver Physiology 300, G273–G282 (2011).
- van Dop, W. A. et al. The absence of functional PI3Kγ prevents leukocyte recruitment and ameliorates DSS-induced colitis in mice. Immunology Letters 131, 33–39 (2010).
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- Sina, C. et al. Ablation of gly96/immediate early gene-X1 (gly96/iex-1) aggravates DSS-induced colitis in mice: Role for gly96/iex-1 in the regulation of NF-κB. Inflamm Bowel Dis 16, 320–331 (2010).
- Sánchez-Fidalgo, S. et al. Extra-virgin olive oil-enriched diet modulates DSS-colitis-associated colon carcinogenesis in mice. Clinical Nutrition 29, 663–673 (2010).
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- Konerding, M. A. et al. Inflammation-Induced Intussusceptive Angiogenesis in Murine Colitis. The Anatomical Record 293, 849–857 (2010).
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- Edelson, B. T. et al. Peripheral CD103+ dendritic cells form a unified subset developmentally related to CD8α+ conventional dendritic cells. Journal of Experimental Medicine 207, 823–836 (2010).
- DeBoer, M. D., Li, Y. & Cohn, S. Colitis causes delay in puberty in female mice out of proportion to changes in leptin and corticosterone. J Gastroenterol 45, 277–284 (2010).
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- Schreiber, O. et al. Lactobacillus reuteri prevents colitis by reducing P-selectin-associated leukocyte- and platelet-endothelial cell interactions. American Journal of Physiology-Gastrointestinal and Liver Physiology 296, G534–G542 (2009).
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- Canevari, M. et al. Poly(ethylene glycol)-mesalazine conjugate for colon specific delivery. International Journal of Pharmaceutics 368, 171–177 (2009).
- Banerjee, S. et al. MEP1A allele for meprin A metalloprotease is a susceptibility gene for inflammatory bowel disease. Mucosal Immunol 2, 220–231 (2009).
- Voltan, S. et al. Lactobacillus crispatus M247-Derived H2O2 Acts as a Signal Transducing Molecule Activating Peroxisome Proliferator Activated Receptor-γ in the Intestinal Mucosa. Gastroenterology 135, 1216–1227 (2008).
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- Fritsch Fredin, M. et al. The application and relevance of ex vivo culture systems for assessment of IBD treatment in murine models of colitis. Pharmacological Research 58, 222–231 (2008).
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- Castagliuolo, I. et al. Beneficial effect of auto-aggregating Lactobacillus crispatus on experimentally induced colitis in mice. FEMS Immunol Med Microbiol 43, 197–204 (2005).
- Brun, P. et al. Neuropeptide neurotensin stimulates intestinal wound healing following chronic intestinal inflammation. American Journal of Physiology-Gastrointestinal and Liver Physiology 288, G621–G629 (2005).
- Bennink, R. J. et al. Dedicated Pinhole SPECT of Intestinal Neutrophil Recruitment in a Mouse Model of Dextran Sulfate Sodium–Induced Colitis. J Nucl Med 46, 526–531 (2005).
- Leemans, J. C. et al. The Epidermal Growth Factor-Seven Transmembrane (EGF-TM7) Receptor CD97 Is Required for Neutrophil Migration and Host Defense. The Journal of Immunology 172, 1125–1131 (2004).
- Edalat, M., Mannervik, B. & Axelsson, L.-G. Selective expression of detoxifying glutathione transferases in mouse colon: effect of experimental colitis and the presence of bacteria. Histochem Cell Biol 122, 151–159 (2004).
- Bene, L. et al. Partial Protection against Dextran Sodium Sulphate Induced Colitis in Histamine-Deficient, Histidine Decarboxylase Knockout Mice. Journal of Pediatric Gastroenterology and Nutrition 39, 171 (2004).
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- Milde, A. M., Sundberg, H., RØseth, A. G. & Murison, R. Proactive Sensitizing Effects of Acute Stress on Acoustic Startle Responses and Experimentally Induced Colitis in Rats: Relationship to Corticosterone. Stress 6, 49–57 (2003).
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- Börjesson, L. & Delbro, D. S. Neurogenic and non-neurogenic mechanisms in response of rat distal colon muscle to dextran sulphate sodium treatment. Autonomic Neuroscience 107, 74–80 (2003).
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- Milde, A. M. & Murison, R. A study of the effets of restraint stress on colitis induced by dextran sulphate sodium in singly housed rats. Integrative Physiological & Behavioral Science 37, 140–150 (2002).
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1999-1994
- Stevceva, L., Pavli, P., Buffinton, G., Wozniak, A. & Doe, W. Dextran sodium sulphate-induced colitis activity varies with mouse strain but develops in lipopolysaccharide-unresponsive mice. Journal of Gastroenterology and Hepatology 14, 54–60 (1999).
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- Blackburn, A. C., Doe, W. F. & Buffinton, G. D. Salicylate Hydroxylation as an Indicator of Hydroxyl Radical Generation in Dextran Sulfate-Induced Colitis. Free Radical Biology and Medicine 25, 305–313 (1998).
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