ReproCELL 神經細胞優點
- 第一個於全球商業販售的神經細胞(自 2010 年起)
- 提供穩定可產生多巴胺的神經細胞
- 使用 DNA 重組技術,可創造專屬疾病模式
- 可應用到阿茲海默症與帕金森氏症的相關研究
- 可應用於藥物研發與毒性測試
提供 3 種型態神經前驅細胞供研究使用
正常表達神經細胞生物特徵
Green : bIII-tubulin (neural cell marker)
Red : Throsine Hydroxylase (dopaminergic neuron marker)
培養後,細胞培養液中 的多巴胺濃度增加,顯示神經細胞正常生長。
ReproNeuro Human iPS Cell-derived Neurons
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產品貨號 | 產品名稱 | 產品數量 | 備註說明 |
---|---|---|---|
RCDN001N | ReproNeuro Human iPS Cell-derived Neurons | 3 x 106 cells/vial (frozen, for 1 plate of 96 well plate) | |
RCDN001N | ReproNeuro AD-Mutation Neurons | 3 x 106 cells/vial | |
RCDN003P | ReproNeuro AD-Patient 1 Neurons | 3 x 106 cells/vial |
For replenishing the reagents included in the kits
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產品貨號 | 產品名稱 | 產品數量 | 備註說明 |
---|---|---|---|
RCDN101 | ReproNeuro Culture Medium | 40 mL | |
RCDN102 | ReproNeuro MQ Culture Medium | 40 mL | |
RCDN201 | ReproNeuro Coat | 150 μL |
Additional Publications
- Sugai A; Kato T; Koyama A; Koike Y; Konno T; Ishihara T; Onodera O. Non-genetically modified models exhibit TARDBP mRNA increase due to perturbed TDP-43 autoregulation. Neurobiol Disease 130:104534 (2019).
- Kumagai A; Sasaki T; Matsuoka K; Abe M; Tabata T; Itoh Y; Fuchino H; Wugangerile S; Suga M; Yamaguchi T; Nagaoka Y; Kawabata K; Furue MK; Takemori H. Monitoring of Glutamate‐Induced Excitotoxicity by Mitochondrial Oxygen Consumption. Synapse in press:https//doi.org/1.1002/syn.22067 (2018)
- Murata H; Takamatsu H; Liu S; Kataoka K; Hu N-h; Sakaguchi M. NRF2 Regulates PINK1 Expression under Oxidative Stress Conditions. PLoS One 10:e0142438 (2015).
- Odawara, Aoi, Masao Gotoh, and Ikuro Suzuki. Three-dimensional neuronal culture technique that controls the direction of neurite elongation and the position of soma to mimic the layered structure of the brain. RSC Adv. (2013).
- Bottiglieri, Teodoro, et al.Acute administration of L-DOPA induces changes in methylation metabolites, reduced protein phosphatase 2A methylation, and hyperphosphorylation of Tau protein in mouse brain. The Journal of Neuroscience 32.27 (2012): 9173-9181.
Presentations
- Society for Biomolecular Sciences (SBS), 14th AnnualConference and Exhibition 2008 (St. Louis), poster session, April 2008.
- IBC Asia’s 4th Annual Stem Cells Asia Congress (Singapore), oral session, June 2008.
- ELRIG and SBS Present: Drug Discovery (UK) poster session, September 2008.
- Advances in Stem Cell Discoveries (San Francisco) oral session, September 2008.
- Stem Cells: Drug Discovery and Therapeutics (London) oral session, February 2008.
- Society for Biomolecular Science 15th Annual Conference (France), poster session, Best Poster 2009 Award-winning, April 2009.
- Stem Cells and Regenerative Medicine Europe (UK), September 2009, Best Poster 2009 Award-winning.
- MipTec Conference 2009, October 13-15, Basel Invited Lecture.
- The 74th Annual Scientific Meeting of the Japanese Circulation Society (Kyoto), March 2010.
- The 130th The Pharmaceutical Society of Japan (Okayama), March 2010.
- The Society of Toxicology (SOT) 51st Annual Meeting (CA, USA), poster session, March 2012.
- Safety Pharmacology Society (SPS), 13th annual meeting 2013 (Rotterdam, Netherlands), poster session, September 2013.
- Automated Patch-Clamp systems and Ion Channel Expressing Cells 2013 (Tokyo), Verbal presentation 2013 Nov.
- The 7th Takeda Science Foundation Symposium (Osaka), Poster presentation 2014 Jan.