atelogene in vivo sirnamirna transfection 0827換
atelogene in vivo sirnamirna transfection 0827換

ReproCELL KOKEN AteloGene® in vivo siRNA/miRNA Transfection kit 體內 siRNA/miRNA 轉染試劑

ReproCELL KOKEN AteloGene ，利用 Atelocollagen 和 siRNA 形成複合物，可使 siRNA 在體內轉染的成功率大幅上升。Atelocollagen 為 collagen (膠原蛋白) 切除兩端後的修飾物，更為穩定。在動物模式中可直接進行 siRNA 轉染，利用冷光明顯觀測出效果優於傳統方式。

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分類：其他試劑 > 幹細胞相關產品 > 試劑溶液

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品牌：KOKEN, ReproCELL

原廠介紹 – Local Use
原廠介紹 – Systemic Use

利用 Atelocollagen 和 siRNA 形成複合物，可使 siRNA 在體內轉染的成功率大幅上升。Atelocollagen 為 collagen (膠原蛋白) 切除兩端後的修飾物，更為穩定。在動物模式中可直接進行 siRNA 轉染，利用冷光明顯觀測出效果優於傳統方式。

RS03 transfection kit pic01
RS03 transfection kit pic02

產品優勢

操作簡便

RS03 transfection kit pic03

  • 傳送效率高

  • 維持 siRNA 穩定

  • 生物毒性低

RS03 transfection kit fig01

AteloGene®

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產品貨號產品名稱產品容量備註說明
KKN-1394AteloGene® Local Use*1 Kit含有凝膠物質，可選擇位點注射
KKN-1494AteloGene® Local Use Quick Gelation +1 Kit此為 KKN-1394 的升級版，所需的時間短，效果更好。
KKN-1395AteloGene® Systemic Use*1 Kit不含凝膠物質，可由靜脈注射散佈到全身

* 可執行 10 次注射　+ 可執行 15 次注射

Publications

[Systemic Use]

Cancer research

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Research subjectsNucleic acidsAdministration routesReferencesPubMed ID
Prostate cancer, Lung cancersiRNAintravenous, intratumorTakahashi M,?et al.?(2013) PLoS One 8(8): e73214.23951344
Oral squamous cell carcinomamiRNAintravenousTanaka H,?et al.?(2013) Oral Oncol. 49(6):551-559.23481312
Non-small cell lung carcinoma, breast cancersiRNAintravenousMochizuki S,?et al.?(2012)?J Natl Cancer Inst.?104(12):906-922.22636800
Metastatic osteosarcomamiRNAintravenousOsaki M,?et al.?(2011)?Mol Ther.19(6):1123-1130.21427707
Prostate cancersiRNAintravenousAzuma K,?et al.?(2010)?Biochem Biophys Res Commun.?391(1):1075-1079.20004643
Prostate cancersiRNAintravenousSasaki T,?et al.?Biochem Biophys Res Commun.?(2010) 399(1):79-83.20638364
Metastatic prostate cancermiRNAintravenousTakeshita F,?et al.?(2010)?Mol Ther.18(1):181-187.19738602
Prostate cancersiRNAintravenousMu P,?et al.?(2009)?Int J Cancer.125(12):2978-2990.19422046
Prostate cancersiRNAintravenousHokaiwado N,?et al.?(2008)Carcinogenesis.?29(6):1134-1138.18413363
Metastatic prostate cancersiRNAintravenousTakeshita F,?et al.?(2005)?Proc Natl Acad Sci USA.?102(34):12177-12182.16091473

Various research

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Research subjectsNucleic acidsAdministration routesReferencesPubMed ID
Autoimmune InflammationsiRNAintravenousRaveney BJ,?et al.?(2013) PLoS One. 8(2):e56595.23437182
Endothelial permeability––Hanai K,?et al.?(2012)?J Drug Delivery.Article ID 245835.22506120
Contact hypersensitivitysiRNAintravenousInaba S,?et al.?(2012)?Mol Ther.20(2):356-366.22031237
Autoimmune diabetessiRNAintraperitonealLian G,?et al.?(2012)?J Immunol.188(5):2227-2234 .22291182
Vascular inflammatory diseasemiRNAintravenousSun X,?et al.?(2012)?J Clin Invest.122(6):1973-1990.22622040
Drug- and chemical-induced?siRNAintravenousYoshikawa Y,?et al.?(2012)?Toxicol Appl Pharmacol.?[Epub ahead of print]22841776
acute liver injuries
Limb-girdle muscularsiRNAintravenousKawakami E,?et al.?(2011)?Dev Growth Differ.?53(1):48-54.21261610
dystrophy
ArthritismiRNAintravenousNakasa T,?et al.?(2011)?Arthritis Rheum.Jun;63(6):1582-1590.21425254
Comparison of hepatotoxicity–intravenousOgawa S,?et al.?(2011)?J Toxicol Sci.36(6):751-762.22129739
Autoimmune diabetessiRNAintraperitonealYamada A,?et al.?(2010)?PLoS One.5(9):e12894.20877570
Contact hypersensitivitysiRNAintravenousIshimoto T,?et al.?(2008)?Mol Ther.16(2):387-395.18059372
Muscular dystrophiessiRNAintravenous?Kinouchi N,?et al.?(2008)?Gene Ther.15(15):1126-1130.18323791
(orbital veins)
Contact hypersensitivityantisense ODNintravenousHanai K,?et al.?(2004)?Hum Gene Ther.15(3):263-272.15018735

[Local Use]

Cancer research

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Research subjectsNucleic acidsAdministration routesReferencesPubMed ID
Hepatocellular carcinomasiRNAintratumorDeng Q,?et al.? (2013) Hepatology. [Epub ahead of print]23929653
Oral cancersiRNAperitumoralEndo H,?et al.?(2013) Carcinogenesis. 34(3):560-569.23233740
Osteosarcoma.siRNAintratumorFujiwara-Okada Y,?et al.?(2013) Br J Cancer. 108(4):836-847.23462806
Breast cancersiRNAintratumorKabuta T,?et al.?(2013) J Biol Chem. [Epub ahead of print]23543736
Prostate cancersiRNAperitumoralNomura T?et al.?(2013) Mol Cancer. 12:27.23566222
Renal cancersiRNAperitumorTakeuchi A,?et al.?(2013) Cancer Immunol Immunother. 62(3):517-527.23052245
GliomasiRNAintratumorYamaki T,?et al.?(2013) Sci Rep. 3:1160.23362460
Prostate cancersiRNAintratumorKawamura M,?et al.?(2012) Cell Death Differ. 19(1):170-179.21681193
Premature senescencesiRNAperitumoralKim BC?et al.?(2012)?EMBO J.31(22):4289-4303.23085987
Prostate cancershRNAperitumoralKoike K,?et al.?(2012)?Curr Cancer Drug Targets.?12(7):847-856.22515525
GliomasiRNAperitumoralOkazaki T,?et al.?(2012)?Cancer Lett.323(2):199-207.22542810
GliomaplasmidintratumorEl Sayed SM,?et al.?(2012)?Cancer Gene Ther.?19(1):1-18.21921941
Urothelial carcinomasiRNAtransurethralShimada K,?et al.?(2012)?Clin Cancer Res.?18(19):5247-5255.22850567
MesotheliomasiRNAperitumoralSudo H,?et al.?(2012)?Cancer Sci.103(2):203-209.22017350
Embryonal carcinomasiRNAperitumoralUshida H,?et al.?(2012)?J Urol.187(5):1876-1881.22425046
Lung adenocarcinomasiRNAintratumorYamaguchi T,?et al.?(2012)?Cancer Cell.21(3):348-361.22439932
Pancreatic cancersiRNAintratumorYamato I,?et al.?(2012)?Cancer Res.72(18):4829-483922826605
(orthotopic model)
GliomasiRNAperitumoralAndradas C,?et al.?(2011)?Oncogene.30(2):245-252.20818416
Head and neck squamoussiRNAperitumoralArai A,?et al.?(2011)?Cancer Res.71(13):4598-4607.21571861
cell carcinoma
Breast cancersiRNAinside of angioreacterHashimoto A,?et al.?(2011)?PLoS One.6(8):e23359.21858086
Pancreatic cancersiRNAintratumorKobayashi T,?et al.?(2011)?Clin Exp Metastasis.?28(4):367-376.21331750
GliomasiRNAintratumorLorente M,?et al.?(2011)?Cell Death Differ.?18(6):959-973.21233844
Anaplastic large cellmiRNAperitumoralMatsuyama H,?et al.?(2011)?Blood.118(26):6881-689222042699
lymphomainhibitor
Colon cancersiRNAintratumorOh BY,?et al.?(2011)?World J Gastroenterol.?17(20):2563-2571.21633662
Hepatocellular carcinomasiRNAperitumoralShigematsu S,?et al.?(2011)?Exp Cell Res.?317(13):1851-1859.21624362
Scirrhous gastric cancermiRNA?intratumorTakei Y,?et al.?(2011)?Cancer Res.71(4):1442-1453.21169410
expression(orthotopic model)
vector
Ewing’s sarcomasiRNAintratumorTakigami I,?et al.?(2011)?Int J Cancer.128(1):216-226.20648560
Non-small cell lung cancersiRNAperitumoralTasaki M,?et al.?(2011)?Br J Cancer.104(4):700-706.21285982
(orthotopic model)
Renal cell carcinomasiRNAperitumoralTomita S,?et al.?(2011)?Cancer Sci.102(1):57-63.21054677
Endometrial cancermiRNAperitumoralTsuruta T,?et al.?(2011)?Cancer Res.71(20):6450-6462.21868754
Hepatocellular carcinomasiRNAperitumoralVara D,?et al.?(2011)?Cell Death Differ.18(7):1099-1111.21475304
Prostate cancersiRNAintratumorZeng Y,?et al.?(2011)?J Biol Chem.286(16):13985-13994.21357425
Mammary carcinomasiRNAintra-mammary fat padCheng L,?et al.?(2010)?Oncogene.29(42):5700-5711.20676140
(orthotopic model)
Prostate cancersiRNAperitumoralForootan SS,?et al.?(2010)?Int J Oncol.36(1):69-76.19956834
Cervical cancersiRNAperitumoralHe L,?et al.?(2010)?J Clin Invest.120(6):2094-2108.20458142
Head and neck carcinomamiRNA?peritumoralLiu CJ,?et al.?(2010)?Cancer Res.70(4):1635-1644.20145132
inhibitor
MyelomasiRNAperitumoralMarsaud V,?et al.?(2010)?Mol Cancer.9:103.20459741
Ewing’s sarcomasiRNAintratumorNagano A,?et al.?(2010)?Int J Cancer.126(12):2790-2798.19642105
Hepatocellular carcinomasiRNAintratumorSatow R,?et al.?(2010)?Clin Cancer Res.16(9):2518-2528.20388846
Colorectal cancersiRNAintratumorShitashige M,?et al.?(2010)?Cancer Res.70(12):5024-5033.20530691
MesotheliomasiRNAperitumoralSudo H,?et al.?(2010)?Genomics.95(4):210-216.20153416
p53 mutationsiRNAperitumoralTanooka H,?et al.?(2010)?Cancer Gene Ther.?17(1):1-10.19557034
MyelomasiRNAperitumoralAshihara E,?et al.?(2009 )?Clin Cancer Res.?15(8):2731-2738.19351774
GliomasiRNAperitumoralLorente M,?et al.?(2009)?Glia.57(13):1374-1385.19229996
Bladder cancersiRNAtransurethralShimada K,?et al.?(2009)?Cancer Res.69(7):3157-3164.19293182
Prostate cancersiRNAperitumoralShimada K,?et al.?(2009)?Cancer Sci.100(7):1248-1254.19432893
OsteosarcomasiRNAintratumorYamaguchi U,?et al.?(2009)?Cancer Sci.100(12):2268-2274.19725836
Breast cancersiRNAintratumorBernard-Pierrot I,?et al.?(2008)?Cancer Res.?68(17):7165-7175.18757432
Breast cancersiRNAintratumorHonma K,?et al.?(2008)?Nat Med.14(9):939-948.18724378
(orthotopic model)
Pancreatic cancersiRNAintratumorIwaki K,?et al.?(2008)?Int J Cancer.122(3):658-663.17935125
Non-small cell lung?siRNAperitumoralMigita T,?et al.?(2008)?Cancer Res.68(20):8547-8554.18922930
cancer
Salivary adenoid?siRNAintratumorShirasaki T,?et al.?(2008)?BMC Cancer.8:348.19036131
cystic carcinoma
MelanomasiRNAperitumoralUeno Y,?et al.?(2008)?Int J Cancer.123(2):340-347.18398842
Cervical cancersiRNAintratumorYamato K,?et al.?(2008)?Cancer Gene Ther.?15(3):140-153.18157144
Cervical cancersiRNAintratumorYu D,?et al.?(2008)?Cancer Sci.99(4):810-815.18377429
CholangiocarcinomasiRNAintratumorKokuryo T,?et al.?(2007)?Cancer Res.67(20):9637-9642.17942892
Gastrointestinal cancer,antisenseintratumor,?Nakazawa K,?et al.?(2007)?Cancer.109(5):993-1002.17318877
RhabdomyosarcomaODNintraperitoneal,
intramuscular
Colon cancermiRNAperitumoralTazawa H,?et al.?(2007)?Proc Natl Acad Sci U S A.?104(39):15472-15477.17875987
Ovarian carcinomasiRNAperitumoralYamashita M,?et al.?(2007)?Int J Cancer.?120(10):2243-2250.17266036
Cervical cancersiRNAintratumorFujii T,?et al.?(2006)?Int J Oncol.29(3):541-548.16865269
Head and neck squamous?siRNAintratumorNozawa H,?et al.?(2006)?Cancer Sci.97(10):1115-1124.16984384
cell carcinoma
Prostate cancersiRNAintratumorTakei Y,?et al.?(2006)?Cancer.107(4):864-873.16832814
Cervical cancersiRNAperitumoralKuroda M,?et al.?(2005)?Br J Cancer.92(2):290-293.15655544
Prostate cancerantisense ODNperitumoralTakei Y,?et al.?(2005)?Int J Cancer.114(3):490-497.15578698
Non-seminomatoussiRNAintratumorMinakuchi Y,?et al.?(2004)?Nucleic Acids Res.?32(13):e109.15272050
germcell tumor(orthotopic model)
Prostate cancersiRNAperitumoralTakei Y,?et al.?(2004)?Cancer Res.64(10):3365-3370.15150085
Germ cell tumorantisense ODNperitumoralHirai K,?et al.?(2003)?J Gene Med.5(11):951-957.14601132
Rectal carcinomaantisenseintratumorTakei Y,?et al.?(2002)?J Biol Chem.277(26):23800-23806.11959856
ODN
Rectal carcinomaantisenseperitumoralTakei Y,?et al.?(2001)?Cancer Res.61(23):8486-8491.11731432
ODN

Various research

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Research subjectsNucleic acidsAdministration routesReferencesPubMed ID
Muscular atrophysiRNAintramuscularKawakami E,?et al.?(2013) PLoS One. 8(5):e64719.23717655
Bone fracturesiRNAfracture siteKawakami Y,?et al.?(2013) Lab Invest. [Epub ahead of print]23897412
SclerodermasiRNAintracutaneousMakino K,?et al.?(2013) J Immunol. 190(8):3905-3915.23509348
HypertensionsiRNAmicroinjection to RVLMMatsukawa R,?et al.?(2013) Am J Hypertens. 26 (1): 51-57.23382327
Spinal cord injurysiRNAintrathecalAndo T,?et al.?(2012) PLoS One 7(12): e51744.20181596
FibrosissiRNAintracutaneousDistler A,?et al.?(2012) Ann Rheum Dis. 72(9):1575-1580.23148305
FibrosissiRNAintracutaneousHorn A,?et al.?(2012) Ann Rheum Dis. 71:785-789.22402139
FibrosissiRNAintracutaneousKhodzhigorova A,?et al.?(2012)?Ann Rheum Dis.?[Epub ahead of print]22904261
AsthmasiRNAtracheal catheterLiu S,?et al.?(2012)?Immunol Cell Biol.?90(3):337-345.21625250
Corneal injuryshRNAsubconjunctivalBellner L,?et al.?(2011)?Mol Vis.17:1144-1152.21552471
HypertensionsiRNAmicroinjection to RVLMMatsukawa R,?et al.?(2011)?J Hypertens.?29(9):1735-1742.21738056
Spinal cord injurysiRNAcontused cord surfaceToyooka T,?et al.?(2011)?J Neurotrauma.?28(4):607-618.21250919
Nickel allergysiRNAear pinnaeWatanabe M,?et al.?(2011)?PLoS One.?6(4):e19017.21544193
Muscle injurymiRNAmuscle defect areaNakasa T,?et al.?(2010)?J Cell Mol Med.?14(10):2495-2505.19754672
ArthritismiRNAntraarticularNagata Y,?et al.?(2009)?Arthritis Rheum.?60(9):2677-2683.19714650
Progressive multifocal?siRNAmicroinjection to?Matoba T,?et al.?(2008)Neuropathology.?28(3):286-294.18179406
leukoencephalopathystriatum
Intimal hyperplasiasiRNAsurface of vein graftBanno H,?et al.?(2006)?J Vasc Surg.?44(3):633-641.16950446
Endothelial dysfunctionplasmidintramuscularShinozaki K,?et al.?(2005)Cardiovasc Pharmacol.?46(4):505-512.16160605
Familial amyloidotic polyneuropathysingle-liverNakamura M,?et al.?(2004)?Gene Ther.?11(10):838-846.14961068
stranded ODN
Repeated administration of adenovirus vectoradenovirusintraperitonealOchiya T,?et al.?(2001)?Curr Gene Ther.?1(1):31-52.12109137
vector