atelogene in vivo sirnamirna transfection 0827換

ReproCELL KOKEN AteloGene® in vivo siRNA/miRNA Transfection kit 體內 siRNA/miRNA 轉染試劑

ReproCELL KOKEN AteloGene ,利用 Atelocollagen 和 siRNA 形成複合物,可使 siRNA 在體內轉染的成功率大幅上升。Atelocollagen 為 collagen (膠原蛋白) 切除兩端後的修飾物,更為穩定。在動物模式中可直接進行 siRNA 轉染,利用冷光明顯觀測出效果優於傳統方式。

brands logo KOKEN
brands logo Reprocell

標籤:

品牌:KOKEN, ReproCELL

原廠介紹 – Local Use
原廠介紹 – Systemic Use

利用 Atelocollagen 和 siRNA 形成複合物,可使 siRNA 在體內轉染的成功率大幅上升。Atelocollagen 為 collagen (膠原蛋白) 切除兩端後的修飾物,更為穩定。在動物模式中可直接進行 siRNA 轉染,利用冷光明顯觀測出效果優於傳統方式。

RS03 transfection kit pic01
RS03 transfection kit pic02

產品優勢

操作簡便

RS03 transfection kit pic03
  • 傳送效率高

  • 維持 siRNA 穩定

  • 生物毒性低

RS03 transfection kit fig01

AteloGene®

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產品貨號 產品名稱 產品容量 備註說明
KKN-1394 AteloGene® Local Use* 1 Kit 含有凝膠物質,可選擇位點注射
KKN-1494 AteloGene® Local Use Quick Gelation + 1 Kit 此為 KKN-1394 的升級版,所需的時間短,效果更好。
KKN-1395 AteloGene® Systemic Use* 1 Kit 不含凝膠物質,可由靜脈注射散佈到全身

* 可執行 10 次注射 + 可執行 15 次注射

Publications

[Systemic Use]

Cancer research

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Research subjects Nucleic acids Administration routes References PubMed ID
Prostate cancer, Lung cancer siRNA intravenous, intratumor Takahashi M,?et al.?(2013) PLoS One 8(8): e73214. 23951344
Oral squamous cell carcinoma miRNA intravenous Tanaka H,?et al.?(2013) Oral Oncol. 49(6):551-559. 23481312
Non-small cell lung carcinoma, breast cancer siRNA intravenous Mochizuki S,?et al.?(2012)?J Natl Cancer Inst.?104(12):906-922. 22636800
Metastatic osteosarcoma miRNA intravenous Osaki M,?et al.?(2011)?Mol Ther.19(6):1123-1130. 21427707
Prostate cancer siRNA intravenous Azuma K,?et al.?(2010)?Biochem Biophys Res Commun.?391(1):1075-1079. 20004643
Prostate cancer siRNA intravenous Sasaki T,?et al.?Biochem Biophys Res Commun.?(2010) 399(1):79-83. 20638364
Metastatic prostate cancer miRNA intravenous Takeshita F,?et al.?(2010)?Mol Ther.18(1):181-187. 19738602
Prostate cancer siRNA intravenous Mu P,?et al.?(2009)?Int J Cancer.125(12):2978-2990. 19422046
Prostate cancer siRNA intravenous Hokaiwado N,?et al.?(2008)Carcinogenesis.?29(6):1134-1138. 18413363
Metastatic prostate cancer siRNA intravenous Takeshita F,?et al.?(2005)?Proc Natl Acad Sci USA.?102(34):12177-12182. 16091473

Various research

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Research subjects Nucleic acids Administration routes References PubMed ID
Autoimmune Inflammation siRNA intravenous Raveney BJ,?et al.?(2013) PLoS One. 8(2):e56595. 23437182
Endothelial permeability Hanai K,?et al.?(2012)?J Drug Delivery.Article ID 245835. 22506120
Contact hypersensitivity siRNA intravenous Inaba S,?et al.?(2012)?Mol Ther.20(2):356-366. 22031237
Autoimmune diabetes siRNA intraperitoneal Lian G,?et al.?(2012)?J Immunol.188(5):2227-2234 . 22291182
Vascular inflammatory disease miRNA intravenous Sun X,?et al.?(2012)?J Clin Invest.122(6):1973-1990. 22622040
Drug- and chemical-induced? siRNA intravenous Yoshikawa Y,?et al.?(2012)?Toxicol Appl Pharmacol.?[Epub ahead of print] 22841776
acute liver injuries
Limb-girdle muscular siRNA intravenous Kawakami E,?et al.?(2011)?Dev Growth Differ.?53(1):48-54. 21261610
dystrophy
Arthritis miRNA intravenous Nakasa T,?et al.?(2011)?Arthritis Rheum.Jun;63(6):1582-1590. 21425254
Comparison of hepatotoxicity intravenous Ogawa S,?et al.?(2011)?J Toxicol Sci.36(6):751-762. 22129739
Autoimmune diabetes siRNA intraperitoneal Yamada A,?et al.?(2010)?PLoS One.5(9):e12894. 20877570
Contact hypersensitivity siRNA intravenous Ishimoto T,?et al.?(2008)?Mol Ther.16(2):387-395. 18059372
Muscular dystrophies siRNA intravenous? Kinouchi N,?et al.?(2008)?Gene Ther.15(15):1126-1130. 18323791
(orbital veins)
Contact hypersensitivity antisense ODN intravenous Hanai K,?et al.?(2004)?Hum Gene Ther.15(3):263-272. 15018735

[Local Use]

Cancer research

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Research subjects Nucleic acids Administration routes References PubMed ID
Hepatocellular carcinoma siRNA intratumor Deng Q,?et al.? (2013) Hepatology. [Epub ahead of print] 23929653
Oral cancer siRNA peritumoral Endo H,?et al.?(2013) Carcinogenesis. 34(3):560-569. 23233740
Osteosarcoma. siRNA intratumor Fujiwara-Okada Y,?et al.?(2013) Br J Cancer. 108(4):836-847. 23462806
Breast cancer siRNA intratumor Kabuta T,?et al.?(2013) J Biol Chem. [Epub ahead of print] 23543736
Prostate cancer siRNA peritumoral Nomura T?et al.?(2013) Mol Cancer. 12:27. 23566222
Renal cancer siRNA peritumor Takeuchi A,?et al.?(2013) Cancer Immunol Immunother. 62(3):517-527. 23052245
Glioma siRNA intratumor Yamaki T,?et al.?(2013) Sci Rep. 3:1160. 23362460
Prostate cancer siRNA intratumor Kawamura M,?et al.?(2012) Cell Death Differ. 19(1):170-179. 21681193
Premature senescence siRNA peritumoral Kim BC?et al.?(2012)?EMBO J.31(22):4289-4303. 23085987
Prostate cancer shRNA peritumoral Koike K,?et al.?(2012)?Curr Cancer Drug Targets.?12(7):847-856. 22515525
Glioma siRNA peritumoral Okazaki T,?et al.?(2012)?Cancer Lett.323(2):199-207. 22542810
Glioma plasmid intratumor El Sayed SM,?et al.?(2012)?Cancer Gene Ther.?19(1):1-18. 21921941
Urothelial carcinoma siRNA transurethral Shimada K,?et al.?(2012)?Clin Cancer Res.?18(19):5247-5255. 22850567
Mesothelioma siRNA peritumoral Sudo H,?et al.?(2012)?Cancer Sci.103(2):203-209. 22017350
Embryonal carcinoma siRNA peritumoral Ushida H,?et al.?(2012)?J Urol.187(5):1876-1881. 22425046
Lung adenocarcinoma siRNA intratumor Yamaguchi T,?et al.?(2012)?Cancer Cell.21(3):348-361. 22439932
Pancreatic cancer siRNA intratumor Yamato I,?et al.?(2012)?Cancer Res.72(18):4829-4839 22826605
(orthotopic model)
Glioma siRNA peritumoral Andradas C,?et al.?(2011)?Oncogene.30(2):245-252. 20818416
Head and neck squamous siRNA peritumoral Arai A,?et al.?(2011)?Cancer Res.71(13):4598-4607. 21571861
cell carcinoma
Breast cancer siRNA inside of angioreacter Hashimoto A,?et al.?(2011)?PLoS One.6(8):e23359. 21858086
Pancreatic cancer siRNA intratumor Kobayashi T,?et al.?(2011)?Clin Exp Metastasis.?28(4):367-376. 21331750
Glioma siRNA intratumor Lorente M,?et al.?(2011)?Cell Death Differ.?18(6):959-973. 21233844
Anaplastic large cell miRNA peritumoral Matsuyama H,?et al.?(2011)?Blood.118(26):6881-6892 22042699
lymphoma inhibitor
Colon cancer siRNA intratumor Oh BY,?et al.?(2011)?World J Gastroenterol.?17(20):2563-2571. 21633662
Hepatocellular carcinoma siRNA peritumoral Shigematsu S,?et al.?(2011)?Exp Cell Res.?317(13):1851-1859. 21624362
Scirrhous gastric cancer miRNA? intratumor Takei Y,?et al.?(2011)?Cancer Res.71(4):1442-1453. 21169410
expression (orthotopic model)
vector
Ewing’s sarcoma siRNA intratumor Takigami I,?et al.?(2011)?Int J Cancer.128(1):216-226. 20648560
Non-small cell lung cancer siRNA peritumoral Tasaki M,?et al.?(2011)?Br J Cancer.104(4):700-706. 21285982
(orthotopic model)
Renal cell carcinoma siRNA peritumoral Tomita S,?et al.?(2011)?Cancer Sci.102(1):57-63. 21054677
Endometrial cancer miRNA peritumoral Tsuruta T,?et al.?(2011)?Cancer Res.71(20):6450-6462. 21868754
Hepatocellular carcinoma siRNA peritumoral Vara D,?et al.?(2011)?Cell Death Differ.18(7):1099-1111. 21475304
Prostate cancer siRNA intratumor Zeng Y,?et al.?(2011)?J Biol Chem.286(16):13985-13994. 21357425
Mammary carcinoma siRNA intra-mammary fat pad Cheng L,?et al.?(2010)?Oncogene.29(42):5700-5711. 20676140
(orthotopic model)
Prostate cancer siRNA peritumoral Forootan SS,?et al.?(2010)?Int J Oncol.36(1):69-76. 19956834
Cervical cancer siRNA peritumoral He L,?et al.?(2010)?J Clin Invest.120(6):2094-2108. 20458142
Head and neck carcinoma miRNA? peritumoral Liu CJ,?et al.?(2010)?Cancer Res.70(4):1635-1644. 20145132
inhibitor
Myeloma siRNA peritumoral Marsaud V,?et al.?(2010)?Mol Cancer.9:103. 20459741
Ewing’s sarcoma siRNA intratumor Nagano A,?et al.?(2010)?Int J Cancer.126(12):2790-2798. 19642105
Hepatocellular carcinoma siRNA intratumor Satow R,?et al.?(2010)?Clin Cancer Res.16(9):2518-2528. 20388846
Colorectal cancer siRNA intratumor Shitashige M,?et al.?(2010)?Cancer Res.70(12):5024-5033. 20530691
Mesothelioma siRNA peritumoral Sudo H,?et al.?(2010)?Genomics.95(4):210-216. 20153416
p53 mutation siRNA peritumoral Tanooka H,?et al.?(2010)?Cancer Gene Ther.?17(1):1-10. 19557034
Myeloma siRNA peritumoral Ashihara E,?et al.?(2009 )?Clin Cancer Res.?15(8):2731-2738. 19351774
Glioma siRNA peritumoral Lorente M,?et al.?(2009)?Glia.57(13):1374-1385. 19229996
Bladder cancer siRNA transurethral Shimada K,?et al.?(2009)?Cancer Res.69(7):3157-3164. 19293182
Prostate cancer siRNA peritumoral Shimada K,?et al.?(2009)?Cancer Sci.100(7):1248-1254. 19432893
Osteosarcoma siRNA intratumor Yamaguchi U,?et al.?(2009)?Cancer Sci.100(12):2268-2274. 19725836
Breast cancer siRNA intratumor Bernard-Pierrot I,?et al.?(2008)?Cancer Res.?68(17):7165-7175. 18757432
Breast cancer siRNA intratumor Honma K,?et al.?(2008)?Nat Med.14(9):939-948. 18724378
(orthotopic model)
Pancreatic cancer siRNA intratumor Iwaki K,?et al.?(2008)?Int J Cancer.122(3):658-663. 17935125
Non-small cell lung? siRNA peritumoral Migita T,?et al.?(2008)?Cancer Res.68(20):8547-8554. 18922930
cancer
Salivary adenoid? siRNA intratumor Shirasaki T,?et al.?(2008)?BMC Cancer.8:348. 19036131
cystic carcinoma
Melanoma siRNA peritumoral Ueno Y,?et al.?(2008)?Int J Cancer.123(2):340-347. 18398842
Cervical cancer siRNA intratumor Yamato K,?et al.?(2008)?Cancer Gene Ther.?15(3):140-153. 18157144
Cervical cancer siRNA intratumor Yu D,?et al.?(2008)?Cancer Sci.99(4):810-815. 18377429
Cholangiocarcinoma siRNA intratumor Kokuryo T,?et al.?(2007)?Cancer Res.67(20):9637-9642. 17942892
Gastrointestinal cancer, antisense intratumor,? Nakazawa K,?et al.?(2007)?Cancer.109(5):993-1002. 17318877
Rhabdomyosarcoma ODN intraperitoneal,
intramuscular
Colon cancer miRNA peritumoral Tazawa H,?et al.?(2007)?Proc Natl Acad Sci U S A.?104(39):15472-15477. 17875987
Ovarian carcinoma siRNA peritumoral Yamashita M,?et al.?(2007)?Int J Cancer.?120(10):2243-2250. 17266036
Cervical cancer siRNA intratumor Fujii T,?et al.?(2006)?Int J Oncol.29(3):541-548. 16865269
Head and neck squamous? siRNA intratumor Nozawa H,?et al.?(2006)?Cancer Sci.97(10):1115-1124. 16984384
cell carcinoma
Prostate cancer siRNA intratumor Takei Y,?et al.?(2006)?Cancer.107(4):864-873. 16832814
Cervical cancer siRNA peritumoral Kuroda M,?et al.?(2005)?Br J Cancer.92(2):290-293. 15655544
Prostate cancer antisense ODN peritumoral Takei Y,?et al.?(2005)?Int J Cancer.114(3):490-497. 15578698
Non-seminomatous siRNA intratumor Minakuchi Y,?et al.?(2004)?Nucleic Acids Res.?32(13):e109. 15272050
germcell tumor (orthotopic model)
Prostate cancer siRNA peritumoral Takei Y,?et al.?(2004)?Cancer Res.64(10):3365-3370. 15150085
Germ cell tumor antisense ODN peritumoral Hirai K,?et al.?(2003)?J Gene Med.5(11):951-957. 14601132
Rectal carcinoma antisense intratumor Takei Y,?et al.?(2002)?J Biol Chem.277(26):23800-23806. 11959856
ODN
Rectal carcinoma antisense peritumoral Takei Y,?et al.?(2001)?Cancer Res.61(23):8486-8491. 11731432
ODN

Various research

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Research subjects Nucleic acids Administration routes References PubMed ID
Muscular atrophy siRNA intramuscular Kawakami E,?et al.?(2013) PLoS One. 8(5):e64719. 23717655
Bone fracture siRNA fracture site Kawakami Y,?et al.?(2013) Lab Invest. [Epub ahead of print] 23897412
Scleroderma siRNA intracutaneous Makino K,?et al.?(2013) J Immunol. 190(8):3905-3915. 23509348
Hypertension siRNA microinjection to RVLM Matsukawa R,?et al.?(2013) Am J Hypertens. 26 (1): 51-57. 23382327
Spinal cord injury siRNA intrathecal Ando T,?et al.?(2012) PLoS One 7(12): e51744. 20181596
Fibrosis siRNA intracutaneous Distler A,?et al.?(2012) Ann Rheum Dis. 72(9):1575-1580. 23148305
Fibrosis siRNA intracutaneous Horn A,?et al.?(2012) Ann Rheum Dis. 71:785-789. 22402139
Fibrosis siRNA intracutaneous Khodzhigorova A,?et al.?(2012)?Ann Rheum Dis.?[Epub ahead of print] 22904261
Asthma siRNA tracheal catheter Liu S,?et al.?(2012)?Immunol Cell Biol.?90(3):337-345. 21625250
Corneal injury shRNA subconjunctival Bellner L,?et al.?(2011)?Mol Vis.17:1144-1152. 21552471
Hypertension siRNA microinjection to RVLM Matsukawa R,?et al.?(2011)?J Hypertens.?29(9):1735-1742. 21738056
Spinal cord injury siRNA contused cord surface Toyooka T,?et al.?(2011)?J Neurotrauma.?28(4):607-618. 21250919
Nickel allergy siRNA ear pinnae Watanabe M,?et al.?(2011)?PLoS One.?6(4):e19017. 21544193
Muscle injury miRNA muscle defect area Nakasa T,?et al.?(2010)?J Cell Mol Med.?14(10):2495-2505. 19754672
Arthritis miRNA ntraarticular Nagata Y,?et al.?(2009)?Arthritis Rheum.?60(9):2677-2683. 19714650
Progressive multifocal? siRNA microinjection to? Matoba T,?et al.?(2008)Neuropathology.?28(3):286-294. 18179406
leukoencephalopathy striatum
Intimal hyperplasia siRNA surface of vein graft Banno H,?et al.?(2006)?J Vasc Surg.?44(3):633-641. 16950446
Endothelial dysfunction plasmid intramuscular Shinozaki K,?et al.?(2005)Cardiovasc Pharmacol.?46(4):505-512. 16160605
Familial amyloidotic polyneuropathy single- liver Nakamura M,?et al.?(2004)?Gene Ther.?11(10):838-846. 14961068
stranded ODN
Repeated administration of adenovirus vector adenovirus intraperitoneal Ochiya T,?et al.?(2001)?Curr Gene Ther.?1(1):31-52. 12109137
vector