Biocrates AbsoluteIDQ® p180 Kit

心臟代謝疾病 Cardiometabolic Diseases

心臟病 Cardiology

• Associations between branched chain amino acid levels, obesity and cardiometabolic complications Allam-Ndoul et al., 2015
• Effects of metformin on metabolite profiles and LDL cholesterol in patients with type 2 diabetes Xu et al., 2015
• Enzymatically Modified Starch Ameliorates Postprandial Serum Triglycerides and Lipid Metabolome in Growing Pigs Metzler-Zebeli et al., 2015
• Heart-Specific Knockout of the Mitochondrial Thioredoxin Reductase (Txnrd2) Induces Metabolic and Contractile Dysfunction in the Aging Myocardium Kiermayer et al., 2015
• Inverse relations of serum phosphatidylcholines and lysophosphatidylcholines with vascular damage and heart rate in patients with atherosclerosis. Paapstel et al., 2017 Nutr Metab Cardiovasc Dis.
• Metabolic Signature of Remote Ischemic Preconditioning Involving a Cocktail of Amino Acids and Biogenic Amines Chao de la Barca et al., 2016
• Metabolomic fingerprint of heart failure with preserved ejection fraction Zordoky et al., 2015
• Metabolomic profiles of lipid metabolism, arterial stiffness and hemodynamics in male coronary artery disease patients Paapstel et al., 2016
• Metabolomics Reveals New Mechanisms for Pathogenesis in Barth Syndrome and Introduces Novel Roles for Cardiolipin in Cellular Function Sandlers et al., 2016
• Microbiome and metabolome modifying effects of several cardiovascular disease interventions in apo-E−/− mice Ryan et al., 2017 Microbiome

糖尿病 Diabetes

• Alterations of the Lipid Metabolome in Dairy Cows Experiencing Excessive Lipolysis Early Postpartum Humer et al., 2016
• Association between Metabolite Profiles, Metabolic Syndrome and Obesity Status. Allam-Ndoul et al., 2016
• Association of Metabolites with Obesity and Type 2 Diabetes Based on FTO Genotype Kim et al., 2016
• Associations between branched chain amino acid levels, obesity and cardiometabolic complications Allam-Ndoul et al., 2015
• Bezafibrate improves insulin sensitivity and metabolic flexibility in STZ-treated diabetic mice Franko et al., 2016
• Deletion of mouse Alkbh7 leads to obesity Solberg et al., 2013 J Mol Cell Biol 2013, 5 (3), 194–203.
• Di-(2-Ethylhexyl)-Phthalate (DEHP) Causes Impaired Adipocyte Function and Alters Serum Metabolites Klöting et al., 2015
• Early metabolic markers of the development of dysglycemia and type 2 diabetes and their physiological significance Ferrannini et al., 2013 Diabetes 2013, 62 (5), 1730–1737.
• Effects of metformin on metabolite profiles and LDL cholesterol in patients with type 2 diabetes Xu et al., 2015
• Enzymatically Modified Starch Ameliorates Postprandial Serum Triglycerides and Lipid Metabolome in Growing Pigs Metzler-Zebeli et al., 2015
• Genetic Predisposition to an Impaired Metabolism of the Branched-Chain Amino Acids and Risk of Type 2 Diabetes: A Mendelian Randomisation Analysis Lotta et al., 2016 PLOS Medicine
• High fat diet-induced modifications in membrane lipid and mitochondrial-membrane protein signatures precede the development of hepatic insulin resistance in mice. Kahle et al., 2015
• Identification of Serum Metabolites Associated With Risk of Type 2 Diabetes Using a Targeted Metabolomic Approach Floegel et al., 2013 Diabetes 2013, 62 (2), 639–648.
• Improved Glucose Homeostasis in Obese Mice Treated with Resveratrol is Associated with Alterations in the Gut Microbiome Sung et al., 2016 Diabetes
• Increased amino acids levels and the risk of developing of hypertriglyceridemia in a 7-year follow-up Mook et al., 2014
• Lactation is associated with altered metabolomic signatures in women with gestational diabetes Much et al., 2016
• Leptin, acylcarnitine metabolites and development of adiposity in the Rhea mother–child cohort in Crete, Greece Perng et al., 2016 Obesity Science & Practice
• Leucine Supplementation Protects from Insulin Resistance by Regulating Adiposity Levels Binder et al., 2013 PLoS ONE 2013, 8 (9), e74705.
• Maternal cytokine status may prime the metabolic profile and increase risk for obesity in children Englich et al., 2017 International Journal of Obesity
• Metabolic signatures of cultured human adipocytes from metabolically healthy versus unhealthy obese individuals Böhm et al., 2014
• Metabolomic profiling identifies potential pathways involved in the interaction of iron homeostasis with glucose metabolism Stechemesser et al., 2016 Molecular Metabolism
• Metabolomic profiling identifies potential pathways involved in the interaction of iron homeostasis with glucose metabolism. Stechemesser et al., 2017 Molecular Metabolism
• Serum metabolic biomarkers distinguish metabolically healthy peripherally obese from unhealthy centrally obese individuals Gao et al., 2016
• Specific Metabolic Markers Are Associated with Future Waist-Gaining Phenotype in Women Merz et al., 2016
• The Munich MIDY Pig Biobank – A unique resource for studying organ crosstalk in diabetes. Blutke et al., 2017 Molecular Metabolism
• Tryptophan as a Surrogate Prognostic Marker for Diabetic Nephropathy. Chou et al., 2017 J Diabetes Investig.
• Twenty-four-hour rhythmicity of circulating metabolites: effect of body mass and type 2 diabetes Isherwood et al., 2017 FASEB Journal

肝病 Hepatology

• Clinical and Metabolic Characterization of Lean Caucasian Subjects With Non-alcoholic Fatty Liver Feldman et al., 2016
• Diagnosing Fatty Liver Disease: A Comparative Evaluation of Metabolic Markers, Phenotypes, Genotypes and Established Biomarkers Siegert et al., 2013 PLoS ONE 2013, 8 (10), e76813.
• Effects of Perfluorooctanoic Acid on Metabolic Profiles in Brain and Liver of Mouse Revealed by a High-throughput Targeted Metabolomics Approach Yu et al., 2016
• Impaired branched-chain amino acid metabolism may underlie the nonalcoholic fatty liver disease-like pathology of neonatal testosterone-treated female rats. Anzai et al., 2017 Scientific Reports
• Liver Metabolomics Reveals Increased Oxidative Stress and Fibrogenic Potential in Gfrp Transgenic Mice in Response to Ionizing Radiation Cheema et al., 2014
• Loss of the RNA polymerase III repressor MAF1 confers obesity resistance Bonhoure et al., 2015
• Methyl-donor supplementation in obese mice prevents the progression of NAFLD, activates AMPK and decreases acyl-carnitine levels Dahlhoff et al., 2014
• Serum lipid alterations identified in chronic hepatitis B, hepatitis B virus-associated cirrhosis and carcinoma patients Wu et al., Scientific Reports 2017 Scientific Reports
• Targeted liquid chromatography-mass spectrometry analysis of serum acylcarnitines in acetaminophen toxicity in children Bhattacharyya et al., 2014
• The lipid-sensor TREM2 aggravates disease in a model of LCMV-induced hepatitis Kosack et al., 2017 Scientific Reports

腎臟病 Nephrology

• Assessment of metabolomic and proteomic biomarkers in detection and prognosis of progression of renal function in chronic kidney disease Nkuipou-Kenfack et al., 2014
• Metabolites associate with kidney function decline and incident chronic kidney disease in the general population Goek et al., 2013
• Nephrol. Dial. Transplant. 2013, 28 (8), 2131–2138.
• Metabolomic Profiling in Individuals with a Failing Kidney Allograft Bassi et al., 2017 PLOS One
• Plasma and urinary amino acid metabolomic profiling in patients with different levels of kidney function Duranton et al., 2014
• Tryptophan as a Surrogate Prognostic Marker for Diabetic Nephropathy. Chou et al., 2017 J Diabetes Investig.

神經內科 Neurology

• Abnormalities in the Polysomnographic, Adenosine and Metabolic Response to Sleep Deprivation in an Animal Model of Hyperammonemia. Marini et al., 2017 Front Physiol.
• Alzheimer’s disease-like pathology has transient effects on the brain and blood metabolome Pan et al., 2015
• Blood metabolite markers of neocortical amyloid-β burden: discovery and enrichment using candidate proteins Voyle et al., 2016
• Blood metabolite markers of preclinical Alzheimer’s disease in two longitudinally followed cohorts of older individuals Casanova et al., 2016
• Combined Metabolomics and Transcriptomics Approaches to Assess the IL-6 Blockade as a Therapeutic of ALS: Deleterious Alteration of Lipid Metabolism Patin et al., 2016
• Defects in fatty acid amide hydrolase 2 in a male with neurologic and psychiatric symptoms Sirrs et al., 2015
• Disturbance of Plasma Lipid Metabolic Profile in Guillain-Barre Syndrome. Tang et al., 2017 Scientific Reports
• Effect of sleep deprivation on the human metabolome. Davies et al., 2014
• Effects of Perfluorooctanoic Acid on Metabolic Profiles in Brain and Liver of Mouse Revealed by a High-throughput Targeted Metabolomics Approach Yu et al., 2016
• Lack of Sterol Regulatory Element Binding Factor-1c Imposes Glial Fatty Acid Utilization Leading to Peripheral Neuropathy Cermenati et al., 2015
• Metabolomic Profiling of Bile Acids in Clinical and Experimental Samples of Alzheimer’s Disease. Pan et al., 2017 Metabolites
• Metabolic profiling of presymptomatic Huntington’s disease sheep reveals novel biomarkers Skene et al., 2017 Scientific Reports
• Plasma 24-metabolite Panel Predicts Preclinical Transition to Clinical Stages of Alzheimer’s Disease Fiandaca et al., 2015
• Plasma phospholipids and prevalence of mild cognitive impairment and/or dementia in the ARIC Neurocognitive Study (ARIC-NCS) Li et al., 2016
• Profiling of Acylcarnitines in First Episode Psychosis before and after Antipsychotic Treatment. Kriisa et al., 2017 J Proteome Res.
• Prospective associations of plasma phospholipids and mild cognitive impairment/dementia among African Americans in the ARIC Neurocognitive Study Li et al., 2017 Alzheimer’s & Dementia
• Sphingomyelin SM(d18:1/18:0) is Significantly Enhanced in Cerebrospinal Fluid Samples Dichotomized by Pathological Amyloid-β42, Tau, and Phospho-Tau-181 Levels Koal et al., 2014
• Targeted metabolomics and medication classification data from participants in the ADNI1 cohort. St John-Williams et al., 2017 Scientific Data
• Taurine and Epidermal Growth Factor Belong to the Signature of First-Episode Psychosis Koido et al., 2016
• The Brain Metabolome of Male Rats across the Lifespan Zheng et al., 2016
• The ratio of phosphatidylcholines to lysophosphatidylcholines in plasma differentiates healthy controls from patients with Alzheimer’s disease and mild cognitive impairment Klavins K., Koal T., Dallmann G. et al., 2015
• Transcriptional and metabolic adaptation of human neurons to the mitochondrial toxicant MPP(+) Krug et al., 2014

營養和生活方式 Nutrition and Lifestyle

• 12-months metabolic changes among gender dysphoric individuals under cross-sex hormone treatment: a targeted metabolomics study Auer et al., 2016 Scientific Reports
• A Branched-Chain Amino Acid-Related Metabolic Signature Characterizes Obese Adolescents with Non-Alcoholic Fatty Liver Disease. Goffredo et al., 2017 Nutrients
• Application of metabolomics to measure the Alberta “Foodome” Borzouie, Shima Thesis
• Association of Metabolites with Obesity and Type 2 Diabetes Based on FTO Genotype Kim et al., 2016
• Associations between branched chain amino acid levels, obesity and cardiometabolic complications Allam-Ndoul et al., 2015
• Dietary and metabolomic determinants of relapse in ulcerative colitis patients: A pilot prospective cohort study. Keshteli et al., 2017 World J Gastroenterol.
• Effect of sleep deprivation on the human metabolome. Davies et al., 2014
• Effects of smoking and smoking cessation on human serum metabolite profile: results from the KORA cohort study Xu et al., 2013 BMC Med 2013, 11, 60.
• Environmental Enteric Dysfunction is Associated with Carnitine Deficiency and Altered Fatty Acid Oxidation Semba et al., 2017 Ebiomedicine
• Enzymatically Modified Starch Ameliorates Postprandial Serum Triglycerides and Lipid Metabolome in Growing Pigs Metzler-Zebeli et al., 2015
• Fecal metabolome of the Hadza hunter-gatherers: a host-microbiome integrative view Turroni et al., 2016
• High-fat diet-induced acceleration of osteoarthritis is associated with a distinct and sustained plasma metabolite signature. Datta et al., 2017 Scientific Reports
• Identification of Altered Metabolomic Profiles Following a Panchakarma-based Ayurvedic Intervention in Healthy Subjects: The Self-Directed Biological Transformation Initiative (SBTI) Peterson et al., 2016
• Identification of Serum Metabolites Associated With Risk of Type 2 Diabetes Using a Targeted Metabolomic Approach Floegel et al., 2013 Diabetes 2013, 62 (2), 639–648.
• Improved Glucose Homeostasis in Obese Mice Treated With Resveratrol Is Associated With Alterations in the Gut Microbiome. Sung et al., 2016 Diabetes
• Lactation is associated with altered metabolomic signatures in women with gestational diabetes Much et al., 2016
• Leucine Supplementation Protects from Insulin Resistance by Regulating Adiposity Levels Binder et al., 2013 PLoS ONE 2013, 8 (9), e74705.
• Loss of the RNA polymerase III repressor MAF1 confers obesity resistance Bonhoure et al., 2015
• Maternal cytokine status may prime the metabolic profile and increase risk for obesity in children Englich et al., 2017 International Journal of Obesity
• Metabolic alterations in children with environmental enteric dysfunction Semba et al., 2016
• Metabolic profiles of male meat eaters, fish eaters, vegetarians, and vegans from the EPIC-Oxford cohort Schmidt et al., 2015
• Metabolomics evidences plasma and serum biomarkers differentiating two heavy pig breeds Bovo et al., 2016
• Metabolomics of Ramadan fasting: an opportunity for the controlled study of physiological responses to food intake Mathew et al., 2014
• Metabolomics reveals differences in postprandial responses to breads and fasting metabolic characteristics associated with postprandial insulin demand in postmenopausal women Moazzami et al., 2014
• Metabotypes with properly functioning mitochondria and anti-inflammation predict extended productive life span in dairy cows Huber et al., 2016
• Microbiome and metabolome modifying effects of several cardiovascular disease interventions in apo-E−/− mice Ryan et al., 2017 Microbiome
• Plasma amino acids and metabolic profiling of dairy cows in response to a bolus duodenal infusion of leucine Sadri et al., 2017 PLOS One
• Plasma concentrations and intakes of amino acids in male meat-eaters, fish-eaters, vegetarians and vegans: a cross-sectional analysis in the EPIC-Oxford cohort Schmidt et al., 2015
• Serum metabolic biomarkers distinguish metabolically healthy peripherally obese from unhealthy centrally obese individuals Gao et al., 2016
• Specific Metabolic Markers Are Associated with Future Waist-Gaining Phenotype in Women Merz et al., 2016
• The COLON study: Colorectal cancer: Longitudinal, Observational study on Nutritional and lifestyle factors that may influence colorectal tumour recurrence, survival and quality of life. Winkels et al., 2014
• The Human Early-Life Exposome (HELIX): Project Rationale and Design Vrijheid et al., 2014
• The Karlsruhe Metabolomics and Nutrition (KarMeN) Study: Protocol and Methods of a Cross-Sectional Study to Characterize the Metabolome of Healthy Men and Women Bub et al., 2016
• Transglycosylated Starch Improves Insulin Response and Alters Lipid and Amino Acid Metabolome in a Growing Pig Model Newman et al., 2017 Nutrients
• Twenty-four-hour rhythmicity of circulating metabolites: effect of body mass and type 2 diabetes Isherwood et al., 2017 FASEB Journal

腫瘤科學 Oncology

• Absence of PD-L1 on tumor cells is associated with reduced MHC I expression and PD-L1 expression increases in recurrent serous ovarian cancer Aust et al., 2017 Scientific Reports
• Alteration of amino acid and biogenic amine metabolism in hepatobiliary cancers: Findings from a prospective cohort study Stepien et al., 2016
• BCAT1 expression associates with ovarian cancer progression: possible implications in altered disease metabolism Wang et al., 2015
• Comparative metabolomics profiling of isogenic KRAS wild type and mutant NSCLC cells in vitro and in vivo Brunelli et al., 2016
• Different metabolic responses to PI3K inhibition in NSCLC cells harboring wild-type and G12C mutant KRAS. Caiola et al., 2016
• Distinct Lipidomic Landscapes Associated with Clinical Stages of Urothelial Cancer of the Bladder Piyarathna et al., 2017 European Urology Focus
• Functional inhibition of acid sphingomyelinase by Fluphenazine triggers hypoxia-specific tumor cell death. Klutzny et al., 2017 Cell Death Dis.
• Mass Spectrometry-Based Quantitative Metabolomics Revealed a Distinct Lipid Profile in Breast Cancer Patients Qiu et al., 2013 Int J Mol Sci 2013, 14 (4), 8047–8061.
• Metabolic markers in blood can separate prostate cancer from benign prostatic hyperplasia Giskeødegård et al., 2015
• Metabolic Phenotyping Reveals a Lipid Mediator Response to Ionizing Radiation Laiakis et al., 2014
• Metabolomic profile in pancreatic cancer patients: a consensusbased approach to identify highly discriminating metabolites Di Gangi et al., 2015
• Metabolomics for Biomarker Discovery in Gastroenterological Cancer Nishiumi et al., 2014
• Modulation of plasma metabolite biomarkers of MAPK pathway with the MEK inhibitor RO4987655: pharmacodynamic and predictive potential in metastatic melanoma. Ang et al., 2017 Mol Cancer Ther.
• Multi-omics analysis of serum samples demonstrates reprogramming of organ functions via systemic calcium mobilization and platelet activation in metastatic melanoma Muqaku et al., 2016
• Multi-omics Analysis of Serum Samples Demonstrates Reprogramming of Organ Functions Via Systemic Calcium Mobilization and Platelet Activation in Metastatic Melanoma. Mugaku et al., 2017 Mol Cell Proteomics
• Phamacometabolomics study identifies circulating spermidine and tryptophan as potential biomarkers associated with the complete pathological response to trastuzumab-paclitaxel neoadjuvant therapy in HER-2 positive breast cancer Miolo et al., 2016
• Plasma Metabolomic Changes following PI3K Inhibition as Pharmacodynamic Biomarkers: Preclinical Discovery to Phase I Trial Evaluation. Ang et al., 2016
• Pre-diagnostic metabolite concentrations and prostate cancer risk in 1077 cases and 1077 matched controls in the European Prospective Investigation into Cancer and Nutrition. Schmidt et al., 2017 BMC Medicine
• Serum lipid alterations identified in chronic hepatitis B, hepatitis B virus-associated cirrhosis and carcinoma patients Wu et al., Scientific Reports 2017 Scientific Reports
• The COLON study: Colorectal cancer: Longitudinal, Observational study on Nutritional and lifestyle factors that may influence colorectal tumour recurrence, survival and quality of life. Winkels et al., 2014

藥物研究 Pharmaceutical Research

• Bezafibrate improves insulin sensitivity and metabolic flexibility in STZ-treated diabetic mice Franko et al., 2016
• Characterization of a metabolomic profile associated with responsiveness to therapy in the acute phase of septic shock. Cambiaghi et al., 2017 Scientific Reports
• Characterization of a rat model of moderate liver dysfunction based on alpha-naphthylisothiocyanate-induced cholestasis. Bothe et al., 2017 J Toxicol Sci.
• Combined Metabolomics and Transcriptomics Approaches to Assess the IL-6 Blockade as a Therapeutic of ALS: Deleterious Alteration of Lipid Metabolism Patin et al., 2016
• Comparative metabolomics profiling of isogenic KRAS wild type and mutant NSCLC cells in vitro and in vivo Brunelli et al., 2016
• Di-(2-Ethylhexyl)-Phthalate (DEHP) Causes Impaired Adipocyte Function and Alters Serum Metabolites Klöting et al., 2015
• Different metabolic responses to PI3K inhibition in NSCLC cells harboring wild-type and G12C mutant KRAS. Caiola et al., 2016
• Differential cellular metabolite alterations in HaCaT cells caused by exposure to the aryl hydrocarbon receptor-binding polycyclic aromatic hydrocarbons chrysene, benzo[a]pyrene and dibenzo[a,l]pyrene Potratz et al., 2016
• Effects of metformin on metabolite profiles and LDL cholesterol in patients with type 2 diabetes Xu et al., 2015
• Effects of Perfluorooctanoic Acid on Metabolic Profiles in Brain and Liver of Mouse Revealed by a Highthroughput Targeted Metabolomics Approach Yu et al., 2017 Scientific Reports
• Identification of Altered Metabolomic Profiles Following a Panchakarma-based Ayurvedic Intervention in Healthy Subjects: The Self-Directed Biological Transformation Initiative (SBTI) Peterson et al., 2016
• Liver Metabolomics Reveals Increased Oxidative Stress and Fibrogenic Potential in Gfrp Transgenic Mice in Response to Ionizing Radiation Cheema et al., 2014
• Metabolic Phenotyping Reveals a Lipid Mediator Response to Ionizing Radiation Laiakis et al., 2014
• Microbiome and metabolome modifying effects of several cardiovascular disease interventions in apo-E−/− mice Ryan et al., 2017 Microbiome
• Modulation of plasma metabolite biomarkers of MAPK pathway with the MEK inhibitor RO4987655: pharmacodynamic and predictive potential in metastatic melanoma. Ang et al., 2017 Mol Cancer Ther.
• Perinatal exposure to glyphosate-based herbicide alters the thyrotrophic axis and causes thyroid hormone homeostasis imbalance in male rats de Souza et al., 2017 Toxicology
• Phamacometabolomics study identifies circulating spermidine and tryptophan as potential biomarkers associated with the complete pathological response to trastuzumab-paclitaxel neoadjuvant therapy in HER-2 positive breast cancer Miolo et al., 2016
• Plasma Metabolomic Changes following PI3K Inhibition as Pharmacodynamic Biomarkers: Preclinical Discovery to Phase I Trial Evaluation. Ang et al., 2016
• Profiling of Acylcarnitines in First Episode Psychosis before and after Antipsychotic Treatment. Kriisa et al., 2017 J Proteome Res.
• Proteomic and Metabolomic Analyses Reveal Contrasting Anti-Inflammatory Effects of an Extract of Mucor Racemosus Secondary Metabolites Compared to Dexamethasone Meier et al., 2015
• Serum metabolites predict response to angiotensin II receptor blockers in patients with diabetes mellitus Pena et al., 2016
• Targeted liquid chromatography-mass spectrometry analysis of serum acylcarnitines in acetaminophen toxicity in children Bhattacharyya et al., 2014
• Targeted Metabolomic Profiling Indicates Structure-based Perturbations in Serum Phospholipids in Children with Acetaminophen Overdose Bhattacharyya et al., 2016
• Targeted metabolomics of nonhuman primate serum after exposure to ionizing radiation: potential tools for high-throughput biodosimetry Pannkuk et al., 2016
• Taurine and Epidermal Growth Factor Belong to the Signature of First-Episode Psychosis Koido et al., 2016
• Utilization of Metabolomics to Identify Biomarkers in Hematological Malignancies: Role of IDO and the Tryptophan Pathway Finger et al., 2017 Blood

 

其他研究領域 Other Research Fields

老化 Aging

• Aging-related changes in mouse serum glycerophospholipid profiles Kim et al., 2014
• Effect of sleep deprivation on the human metabolome. Davies et al., 2014
• Heart-Specific Knockout of the Mitochondrial Thioredoxin Reductase (Txnrd2) Induces Metabolic and Contractile Dysfunction in the Aging Myocardium Kiermayer et al., 2015
• Lysophosphatidylcholines to phosphatidylcholines ratio predicts advanced knee osteoarthritis Zhang et al., 2016
• Metabolomic analysis of human plasma reveals that arginine is depleted in knee osteoarthritis patients Zhang et al., 2015
• Plasma Biomarkers of Poor Muscle Quality in Older Men and Women from the Baltimore Longitudinal Study of Aging Moaddel et al., 2016
• Proteomics and metabolomics identify molecular mechanisms of aging potentially predisposing for chronic lymphocytic leukemia. Mayer et al., 2017 Mol Cell Proteomics

生物程序 Bioprocessing

• Reduced quenching and extraction time for mammalian cells using filtration and syringe extraction Hernández et al., 2014

流行病學與遺傳學 Epidemiology & Genetics

• Comprehensive metabolic profiling of chronic low-grade inflammation among generally healthy individuals. Pietzner et al., 2017 BMC Medicine
• Effects of smoking and smoking cessation on human serum metabolite profile: results from the KORA cohort study Xu et al., 2013 BMC Med 2013, 11, 60.
• Genetic Predisposition to an Impaired Metabolism of the Branched-Chain Amino Acids and Risk of Type 2 Diabetes: A Mendelian Randomisation Analysis Lotta et al., 2016 PLOS Medicine
• Metabolic profiles of male meat eaters, fish eaters, vegetarians, and vegans from the EPIC-Oxford cohort Schmidt et al., 2015
• Metabolite patterns predicting sex and age in participants of the Karlsruhe Metabolomics and Nutrition (KarMeN) study. Rist et al., 2017 PLOS One
• Plasma concentrations and intakes of amino acids in male meat-eaters, fish-eaters, vegetarians and vegans: a cross-sectional analysis in the EPIC-Oxford cohort Schmidt et al., 2015
• Pre-diagnostic metabolite concentrations and prostate cancer risk in 1077 cases and 1077 matched controls in the European Prospective Investigation into Cancer and Nutrition. Schmidt et al., 2017 BMC Medicine
• Prospective associations of plasma phospholipids and mild cognitive impairment/dementia among African Americans in the ARIC Neurocognitive Study Li et al., 2017 Alzheimer’s & Dementia
• Random Survival Forest in practice: a method for modelling complex metabolomics data in time to event analysis Dietrich et al., 2016
• Reliability of Serum Metabolites over a Two-Year Period: A Targeted Metabolomic Approach in Fasting and Non-Fasting Samples from EPIC Carayol et al., 2015
• Short-term NO 2 exposure is associated with long-chain fatty acids in prospective cohorts from Augsburg, Germany: results from an analysis of 138 metabolites and three exposures Ward-Caviness et al., 2016

消化內科 Gastroenterology

• Dietary and metabolomic determinants of relapse in ulcerative colitis patients: A pilot prospective cohort study. Keshteli et al., 2017 World J Gastroenterol.
• Metabolic alterations in children with environmental enteric dysfunction Semba et al., 2016
• Metabolomics for Biomarker Discovery in Gastroenterological Cancer Nishiumi et al., 2014
• Metabonomics Reveals Metabolite Changes in Biliary Atresia Infants. Zhou et al., 2015

婦科與生育 Gynecology & Fertility

• A metabolomics approach to characterize phenotypes of metabolic transition from late pregnancy to early lactation in dairy cows Kenéz et al., 2016
• A Predictive Metabolic Signature for the Transition from Gestational Diabetes to Type 2 Diabetes Allalou et al., 2016
• Alterations of the Lipid Metabolome in Dairy Cows Experiencing Excessive Lipolysis Early Postpartum Humer et al., 2016
• Impaired branched-chain amino acid metabolism may underlie the nonalcoholic fatty liver disease-like pathology of neonatal testosterone-treated female rats. Anzai et al., 2017 Scientific Reports
• Integrated Proteomic and Metabolomic prediction of Term Preeclampsia. Bahado-Singh et al., 2017 Scientific Reports
• Lactation is associated with altered metabolomic signatures in women with gestational diabetes Much et al., 2016
• Maternal cytokine status may prime the metabolic profile and increase risk for obesity in children Englich et al., 2017 International Journal of Obesity
• Maternal Early Pregnancy Serum Metabolomics Profile and Abnormal Vaginal Bleeding as Predictors of Placental Abruption: A Prospective Study Gelaye et al., 2016
• Metabolomic prediction of fetal congenital heart defect in the first trimester Bahado-Singh et al., 2014
• Metabolomics reveals differences in postprandial responses to breads and fasting metabolic characteristics associated with postprandial insulin demand in postmenopausal women Moazzami et al., 2014
• Metabotypes with properly functioning mitochondria and anti-inflammation predict extended productive life span in dairy cows Huber et al., 2016
• Non-invasive prediction of embryo developmental potential by embryo culture medium quantitative secretomic Camillo et al., 2015
• Perinatal Asphyxia: A Review from a Metabolomics Perspective Fattuoni et al., 2015
• Targeted metabolomics reveals reduced levels of polyunsaturated choline plasmalogens and a smaller dimethylarginine/arginine ratio in the follicular fluid of patients with a diminished ovarian reserve. de la Barca et al., 2017 Hum. Reprod.

炎症和免疫學 Inflammation & Immunology

• Absence of PD-L1 on tumor cells is associated with reduced MHC I expression and PD-L1 expression increases in recurrent serous ovarian cancer Aust et al., 2017 Scientific Reports
• Admission levels of asymmetric and symmetric dimethylarginine predict longterm outcome in patients with communityacquired pneumonia Voegeli et al., 2017
• Blood serum metabolome of atopic dermatitis: Altered energy cycle and the markers of systemic inflammation. Ottas et al., 2017 PLOS One
• Characterization of a metabolomic profile associated with responsiveness to therapy in the acute phase of septic shock. Cambiaghi et al., 2017 Scientific Reports
• Classification of osteoarthritis phenotypes by metabolomics analysis Zhang et al., 2014
• Combined Proteome and Eicosanoid Profiling Approach for Revealing Implications of Human Fibroblasts in Chronic Inflammation Tahir et al., 2017 Analytical Chemistry
• Comprehensive metabolic profiling of chronic low-grade inflammation among generally healthy individuals. Pietzner et al., 2017 BMC Medicine
• Comprehensive proteomic and metabolomic signatures of nontypeable Haemophilus influenzae-induced acute otitis media reveal bacterial aerobic respiration in an immunosuppressed environment Harrison et al., 2015
• High-fat diet-induced acceleration of osteoarthritis is associated with a distinct and sustained plasma metabolite signature. Datta et al., 2017 Scientific Reports
• Hyperglycemia-related advanced glycation end-products is associated with the altered phosphatidylcholine metabolism in osteoarthritis patients with diabetes. Zhang et al, 2017 PLOS One
• Metabolomic Profiling in Individuals with a Failing Kidney Allograft Bassi et al., 2017 PLOS One
• Mortality prediction in patients with severe septic shock: a pilot study using a target metabolomics approach Ferrario et al., 2016
• Multi-omics analysis of serum samples demonstrates reprogramming of organ functions via systemic calcium mobilization and platelet activation in metastatic melanoma Muqaku et al., 2016
• Serum lipid alterations identified in chronic hepatitis B, hepatitis B virus-associated cirrhosis and carcinoma patients Wu et al., Scientific Reports 2017 Scientific Reports
• The lipid-sensor TREM2 aggravates disease in a model of LCMV-induced hepatitis Kosack et al., 2017 Scientific Reports
• The metabolic analysis of psoriasis identifies the associated metabolites while providing computational models for the monitoring of the disease. Ottas et al., 2017 Archives of dermatological research
• Utilization of Metabolomics to Identify Biomarkers in Hematological Malignancies: Role of IDO and the Tryptophan Pathway Finger et al., 2017 Blood

微生物 Microbiome

• Fecal metabolome of the Hadza hunter-gatherers: a host-microbiome integrative view Turroni et al., 2016
• Improved Glucose Homeostasis in Obese Mice Treated with Resveratrol is Associated with Alterations in the Gut Microbiome Sung et al., 2016 Diabetes
• Improved Glucose Homeostasis in Obese Mice Treated With Resveratrol Is Associated With Alterations in the Gut Microbiome. Sung et al., 2016 Diabetes
• Microbiome and metabolome modifying effects of several cardiovascular disease interventions in apo-E−/− mice Ryan et al., 2017 Microbiome

肺病 Pulmonology

• Admission levels of asymmetric and symmetric dimethylarginine predict longterm outcome in patients with communityacquired pneumonia Voegeli et al., 2017
• Endogenous metabolites and inflammasome activity in early childhood and links to respiratory diseases Herberth et al., 2015
• Metabolomics analysis identifies sex-associated metabotypes of oxidative stress and the autotaxin-lysoPA axis in COPD. Naz et al., 2017 The European Respiratory Journal

技術 Technology

• Differential cellular metabolite alterations in HaCaT cells caused by exposure to the aryl hydrocarbon receptor-binding polycyclic aromatic hydrocarbons chrysene, benzo[a]pyrene and dibenzo[a,l]pyrene Potratz et al., 2016
• Optimizing Urine Processing Protocols for Protein and Metabolite Detection Siddiqui et al., 2015
• Random Survival Forest in practice: a method for modelling complex metabolomics data in time to event analysis Dietrich et al., 2016
• Removing the bottlenecks of cell culture metabolomics: fast normalization procedure, correlation of metabolites to cell number, and impact of the cell harvesting method Muschet et al., 2016
• Targeted metabolomics and medication classification data from participants in the ADNI1 cohort. St John-Williams et al., 2017 Scientific Data
• Targeted metabolomics identifies reliable and stable metabolites in human serum and plasma samples Breier et al., 2014
• The human plasma-metabolome: Reference values in 800 French healthy volunteers; impact of cholesterol, gender and age Trabado et al., 2017 PLOS One
• The human saliva metabolome Dame et al., 2015

Brochure

• Biocrates_p180.pdf

Sample Preparation Guidelines

• FS_Guideline_Blood_Sampling_v1-2019.pdf

List of Metabolites

• Biocrates_p180_metabolites.pdf